The Cell, Genes, and DNA

The Cell, Genes, and DNA




Applicable for Courses:

General College Biology I, cell biology, nutrition, and genetics

Educational Level:

Introductory level

Roadmap Objectives:

    • Article: Craig Venter TED Talk. “Craig Venter unveils “synthetic life” Creation of a Bacterial Cell Controlledby a Chemically Synthesized Genome. Daniel G. Gibson,et al., Science 329, 52 (2010);
    • Content area/major concepts: Life, traits of life, cells, prokaryote, eukaryote, cell membrane, DNA, organelles, reproduction, metabolism,/ virus, phace, bacteria, moore’s law, genome, chromosome, cloning, plasmid, restriction, translation, peptides, recombination, PCR
    • Methods or technology used to obtain data:
    • How the CREATE strategy was used:
    • Biggest teaching challenge: I think the BBC news article and the TED talk will be more appropriate for my course. Many of the genetics will be beyond where I would like the conversation. I would like this paper to really grab their attention about, “what is life?”, and to discuss cell structure and function as well as the difference between prokaryotes and eukaryotes.
    • Article: Fructose Metabolism more complicated than was thought. ScienceDaily. December 2008. Hyun-Young Koo et al. Dietery fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. Volume 1782, Issue 5, May 2008, Pages 341–348
    • Content area/major concepts: Fructose, sucrose, carbohydrate, fat, metabolic syndrome, diabetes mellitus, insulin, gene expression, metabolism,
    • Methods or technology used to obtain data: feeding experiment, blood glucose testing, triglyceride testing, liver glycogen content assay, histochemistry, RNA analysis, (G6PD) assay.
    • How the CREATE strategy was used:
    • Biggest teaching challenge: Linking this topic to glycolysis and the electron transport chain. Using it to cover metabolism as a whole and not just diabetes
    • Article: DNA replication protein also has a role in mitosis, cancer. ScienceDaily. May 2012.
    • Content area/major concepts: inheritance, dna replication, genome, genomic instability, birth defect, cancer, mitosis, chromosomes, cell cycle, G1, S, M, G2, protein conformation
    • Methods or technology used to obtain data:
    • How the CREATE strategy was used:
    • Biggest teaching challenge: Making sure they dive into the content of DNA replication, and mitosis. Acronyms.
    • Article: “Trait vs. Fate” (Postnatal Inheritance Section) by Dan Hurley. Discover. May 2013. Weaver, ICG. et al. Epigenetic programming by maternal behavior. Nature neuroscience. Vol 7, Numb 8. August 2004.
    • Content area/major concepts: Genes, DNA, RNA, cytosine, transcription, translation, replication, methyl group, acetyl group, histone, protein, mutation, heritable, hippocampus, stress response, stress hormones, glucocorticoid receptor, postnatal inheritance, in vivo, in vitro, gene expression, transcription factor, exon, promoter, epigenome, chromatin, glial cells, neurons, spermatocyte, oocyte, lysine, causal relationship, adaptive response, phenotype.
    • Methods or technology used to obtain data: Sodium bisulfite mapping Chromatin immunoprecipitation (ChIP) assay Intracerebroventricular infusions Western blotting HPA response to restraint stress
    • How the CREATE strategy was used:
    • Biggest teaching challenge: This article contains a lot of neurobiology on top of the genetics review. My intro students will have no prior exposure to the hippocampus, glial cells, as wells as some of the transcription factors mentioned.

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